The semi-arid region of Chile has gained great relevance in the recent decades mainly due to the constant desertif ication process it's suffering, the increase of climatic extreme events occurrence and the decrease in the precipitation volume. This scenario makes the region a zone of great scientific relevance to the scientific community for the study and analysis of recent climatic events and their relationship with the land cover change process. In this context, satellite technologies now available to Chile could help towards a consistent delivery of updated information from this area. The Satellite System for Earth Observation (SSOT/Fasat-C) controlled by the Chilean Air Force (FACH) carries on board the multispectral sensor NAOMI-1 which has a spatial resolution of 5.8 meters for the blue (455-520 nm), green (528-588 nm), red (625-695 nm) and near infrared (758-881 nm) bands, and a spatial resolution of 1.45 meters for the panchromatic band (455-744 nm). Among its main objectives are land use change detection and monitoring in the Chilean territory, in order to create the basis for a response system in the case of extreme events, and to allow time series study of natural surfaces affected by climate change. In this paper the radiometric calibration and atmospheric correction of a Fasat-Charlie scene was carried out. Spectral signatures of vegetation, bare soil (Aridisol) and concrete were obtained from surface reflectance values. The spectral behavior was then compared with information from the Aster Spectral Library (ASL), and a similar behavior was found. Then, four vegetation indexes were calculated, those are: Simple Ratio (SR), NDVI (Normalized Difference Vegetation Index), LAI (Leaf Area Index) and MSAVI (Modified Soil Adjusted Vegetation Index). The estimated vegetation indexes showed low magnitudes, which could be explained by the scarce characteristics of the vegetation. The MSAVI index showed to be the one that best represented this scarce distribution of the vegetation. These results show the potential that the Fasat-Charlie has as a tool for the monitoring, study and analysis of land covers affected by constant global changes.